Chlorpyrifos

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Chemical Identification | General Product Information | Physical & Safety Data

Chemical Identification

Common Name

Chlorpyrifos

中文通用名

毒死蜱

IUPAC

O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate

CAS

O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate

CAS No.

2921-88-2

Molecular Formula

C₉H₁₁Cl₃NO₃PS

Molecular Structure

General Product Information

Category

Insecticides > Organophosphorus insecticides

Activity

Insecticide

Premix

Sulfoxaflor+Chlorpyrifos
Spirotetramat+Chlorpyrifos
Pymetrozine+Chlorpyrifos
Permethrin+chlorpyrifos
Lambda-cyhalothrin+chlorpyrifos-methyl
Lambda-cyhalothrin+chlorpyrifos+Piperonyl butoxide
Lambda-cyhalothrin+chlorpyrifos
Imidacloprid+Chlorpyrifos+Difenoconazole
Imidacloprid+chlorpyrifos
Fipronil+Chlorpyrifos
Endosulfan+chlorpyrifos
Emamectin benzoate+Chlorpyrifos
Dinotefuran+Chlorpyrifos
Deltamethrin+chlorpyrifos-methyl
Deltamethrin+chlorpyrifos
Chlorpyrifos+cypermethrin
Chlorpyrifos+beta-cypermethrin
Bifenthrin+chlorpyrifos
Beta-cypermethrin+chlorpyrifos-methyl
Beta-cyfluthrin+Chlorpyrifos
Alpha-cypermethrin+chlorpyrifos
Acetamiprid+chlorpyrifos
Abamectin+Chlorpyrifos
Emulsifiable concentrate, dust, flowable, granular bait, wettable powder, microcapsule, pellet, spray. Premix Parters: deltamethrin; flucarbazone-sodium; methabenzthiazuron; metsulfuron-methyl; sulfentrazone sulfometuron-methyl.

Physical & Safety Data

Physical Properties

Molecular weight:350.6; Physical form:Colourless crystals, with a mild mercaptan odour. Density:1.44 (20 °C); Melting point:42-43.5 °C; Vapour pressure:2.7 mPa (25 °C); Henry constant:6.76×10-1 Pa m3 mol-1 (calc.); Partition coefficient(n-octanol and water):logP = 4.7; Solubility:In water c. 1.4 mg/l (25 °C). In benzene 7900, acetone 6500, chloroform 6300, carbon disulfide 5900, diethyl ether 5100, xylene 5000, iso-octanol 790, methanol 450 (all in g/kg, 25 °C).; Stability:Rate of hydrolysis increases with pH, and in the presence of copper and possibly of other metals that can form chelates; DT50 1.5 d (water, pH 8, 25 °C) to 100 d (phosphate buffer). Soluble in acetone, benzene, chloroform, ethanol, iso-octane, methanol, and organic solvents.

Toxicology

Oral:Acute oral LD₅₀ for rats 135-163 mg/kg, guinea pigs 504 mg/kg, rabbits 1000-2000 mg/kg. Percutaneous:Acute percutaneous LD₅₀ for rabbits >5000 mg/kg; (tech.) for rats >2000 mg/kg. Inhalation:LC₅₀ (4-6 h) for rats >0.2 mg/l (14 ppb). Phytotoxicity:Non-phytotoxic to most plant species when used as recommended. Poinsettias, azaleas, camellias, and roses may be injured. ADI:(JMPR) 0.03 mg/kg b.w. [2000].

Environmental Profile

Ecotoxicology:
Algae:NOEC for Selenastrum capricornutum >0.4 mg/l.Bees:Toxic to bees. LD₅₀ (oral) 360 ng/bee; (contact) 70 ng/bee.Birds:Acute oral LD₅₀ for mallard ducks 490 mg/kg, house sparrows (Passer domesticus) 122 mg/kg, chickens 32-102 mg/kg. Dietary LC₅₀ (8 d) for bobwhite quail 423 ppm.Daphnia:LC₅₀ (48 h) 1.7 mg/l.Fish:LC₅₀ (96 h) for goldfish 0.18 (24 h), bluegill sunfish 0.002-0.010 mg/l, rainbow trout 0.007-0.051 mg/l, roach 0.25 mg/l, fathead minnow 0.12-0.54 mg/l, mosquito fish < 1 mg/l.Worms:LC₅₀ (14 d) for Eisenia foetida 210 mg/kg soil.Other aquatic spp.: LC₅₀ for Korean shrimp (Palaemon macrodactylus) 0.05 mg/l.Other beneficial spp.:Toxic to Collembola (J. A. Wiles & G. K. Frampton, Pestic. Sci., 47, 273 (1996)). Environmental fate:
Animals:In rats, dogs, and other mammals, following oral administration, rapid metabolism occurs, the principal metabolite being 3,5,6-trichloropyridin-2-ol. Excretion is principally in the urine.Soil:In soil, chlorpyrifos is degraded at a moderate rate; DT₅₀ (lab.) 10-120 d (25 °C); field DT₅₀ for soil-incorporated applications 33-56 d, for soil-surface applications 7-15 d. Primary route of degradaPlant:Non-systemic in plants, not absorbed from soil via the roots. Residues taken up by plant tissues are metabolised to 3,5,6-trichloropyridin-2-ol which is conjugated and sequestered.WATER SOLUBILITY: 2 ppm at 25°C

Transport Information

Signal Word:CAUTION; Hazard Class:II (Moderately hazardous)