Chromafenozide

Chromafenozide

环虫酰肼

2′-tert-butyl-5-methyl-2′-(3,5-xyloyl)chromane-6-carbohydrazide

3,4-dihydro-5-methyl-2H-1-benzopyran-6-carboxylic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide

143807-66-3

C₂₄H₃₀N₂O₃

Insecticides > Insect growth regulators

Insecticide

Molecular weight:394.5; Physical form:White crystalline powder. Density:1.173 (20 °C); Composition:Tech. is 91%. Melting point:186.4 °C; Vapour pressure:4×10-6 mPa (25 °C); Henry constant:1.41×10-6 Pa m3 mol-1; Partition coefficient(n-octanol and water):logP = 2.7; Solubility:In water 1.12 ppm (20°C). Moderately soluble in polar organic solvents.; Stability:Stable up to 150 °C. Stable for 5 days in aqueous buffers (pH 4.0, 7.0 and 9.0, 50 °C). Photodegradation DT50 in aqueous buffers 5.6-26.1 d.

Oral:Acute oral LD₅₀ for rats and mice >5000 mg/kg. Percutaneous:Acute percutaneous LD₅₀ for rats >2000 mg/kg. Non-irritant to skin; slightly irritant to eyes (rabbits). Mild dermal sensitiser (guinea pigs). Inhalation:LC₅₀ (4 h) for rats >4.68 mg/l air.

Ecotoxicology: Algae:NOEC (3 d) for Selenastrum capricornutum >4.76 mg/l.Bees:LD₅₀ (48 h) for honeybees (contact) >100 mg/bee; (feeding) >133.2 mg/bee.Birds:Acute oral LD₅₀for Japanese quail >5000 mg/kg b.w.Daphnia:LC₅₀ (3 h) for Moina macrocopa >100 mg/l.Fish:LC₅₀ (96 h) for rainbow trout >20, carp >50 mg/l.Worms:LC₅₀ (14 d) for earthworms >1000 mg/kg soil.Other aquatic spp.:LC₅₀ (96 h) for Neocaridina denticulata >200 mg/l.Other beneficial spp.:Safe to predatory mites, wasps and other beneficial species. Environmental fate: Animals:In rats, chromafenozide is rapidly excreted within 48 hours after administration, and is not persistent in tissues and organs. The major component excreted is unchanged chromafenozide.Soil:DT₅₀ for field dissipation 44-113 d (upland soil, 2 sites), 22-136 d (paddy soil, 2 sites). K_oc 236-3780.Plant:In apples, rice and soya beans, many minor metabolites are detected in small amounts, but the major component is unchanged chromafenozide. WATER SOLUBILITY: 1.12 mg/l at 20°C

Hazard Class:O (Obsolete as pesticide, not classified)